Thus, developing behavioral intervention strategies to delay or prevent cognitive decline has increasing importance for public health benefits. The majority of pharmacological phase III randomized controlled trials have failed thus far due to lack of efficacy and/or toxicity. The trial was registered on 29 March 2012 at (ID number NCT01571427).įaced with an aging population and a growing number of people with dementia, it is critical that we develop effective pharmacological and non-pharmacological prevention treatments. Increasing potential participants’ familiarity with a personal computer and the internet before trial recruitment could increase participation rates and improve the generalizability of future studies of this type. Compared with the no interest group, the committed with interest group were more likely to be personal computer users (odds ratio (OR) = 2.78), physically active (OR = 1.03) and had higher levels of loneliness (OR = 1.16). Among them, 309 showed interest in the study and provided their contact information (operationally defined as the committed with interest group), 74 provided contact information without interest in the study (committed without interest group), 66 showed interest, but provided no contact information (interest only group), and 534 showed no interest and provided no contact information (no interest group). Of 1,102 surveys returned (55.1% response rate), 983 surveys had complete data for all the variables of interest. ![]() ![]() We also asked for their contact information if they were interested in being contacted as potential participants in the trial. Two thousand mail-in surveys were distributed to retirement communities in order to collect data on demographics, the nature and frequency of social activities, personal computer use and additional health-related variables, and interest in the prevention study. To examine the selectivity of samples, we conducted a mass mail-in survey distribution among community-dwelling older adults, assessing factors associated with a willingness to participate in the trial. We developed a randomized controlled trial to examine whether conversation-based cognitive stimulation delivered through personal computers, a webcam and the internet would have a positive effect on cognitive function among older adults with normal cognition or mild cognitive impairment. These participants’ characteristics could reduce the generalizability of study results and, more importantly, mask trial effects. ![]() Those willing to volunteer for these trials could be socially active, in relatively good health, and have high educational levels and cognitive function. One challenge in these prevention trials is sample recruitment bias. Trials aimed at preventing cognitive decline through cognitive stimulation among those with normal cognition or mild cognitive impairment are of significant importance in delaying the onset of dementia and reducing dementia prevalence.
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